The simple answer is ‘Yes’ but it does depend on which version of Act! you are using and it may require some Hotfixes to be applied.
Act! v17 will work with Windows 10 but depending on which version you are using it will require a hotfix to be applied otherwise when adding documents Act! will crash.
The Knowledge Base article below has links for v17.1 and v17.2 hotfixes
If you are using Act! 2013 or earlier the advice from Swiftpage is NOT to upgrade to Windows 10 until you have upgrade Act!
As always if you have any questions then give us a call and we can help with any upgrades.